Jimmy asks Rob Lowe's sons Matthew and John Owen a series of random questions about their dad to determine which son knows him best. Subscribe NOW to The Tonight Show Starring Jimmy Fallon: http://bit.ly/1nwT1aN Watch The Tonight Show Starring Jimmy Fallon Weeknights 11:35/10:35c Get more Jimmy Fallon: Follow Jimmy: http://Twitter.com/JimmyFallon Like Jimmy: https://Facebook.com/JimmyFallon Get more The Tonight Show Starring Jimmy Fallon: Follow The Tonight Show: http://Twitter.com/FallonTonight Like The Tonight Show: https://Facebook.com/FallonTonight The Tonight Show Tumblr: http://fallontonight.tumblr.com/ Get more NBC: NBC YouTube: http://bit.ly/1dM1qBH Like NBC: http://Facebook.com/NBC Follow NBC: http://Twitter.com/NBC NBC Tumblr: http://nbctv.tumblr.com/ The Tonight Show Starring Jimmy Fallon features hilarious highlights from the show including: comedy sketches, music parodies, celebrity interviews, ridiculous games, and, of course, Jimmy's Thank You Notes and hashtags! You'll also find behind the scenes videos and other great web exclusives. Best Son Challenge with Rob Lowe and His Sons http://www.youtube.com/fallontonight
Jimmy and Mark Ruffalo take turns drawing questions from the best friends box and guessing each other's answers. Subscribe NOW to The Tonight Show Starring Jim
After seeing one of Ray Romano's sons, Matt, on 'Jimmy Kimmel Live' angling for a girlfriend, James asks Ray and Julia Louis-Dreyfus to help Greg, Ray's other s
Jimmy and Michael Strahan take turns dropping discs into random cups filled with frosé, jalapeño juice and more, then force each other to drink the contents i
Rob Lowe discusses the roles that make up his career, including 'The Outsiders,' 'St. Elmo's Fire,' 'A New Kind of Family,' 'Saturday Night Live,' 'Wayne's Worl
Dax Shepard loves Brad Pitt and Jay Z. More specifically, he'd love to go camping with them.
James challenges Kevin Bacon to identify the jury foreman from his 1992 film, A Few Good Men.
Jimmy asks Steve Martin and Martin Short random questions pulled from the best friends box and has them take turns guessing each other's answers. Subscribe NOW
Rob Lowe’s son John Owen has made his mark online by making snarky comments on his dad’s Instagram. Ellen invited Johnny to sit backstage and troll his dad
Harrison Ford shares his favorite pastime with Jimmy - sipping a good scotch while sharing a good joke. Subscribe NOW to The Tonight Show Starring Jimmy Fallon
Reese Witherspoon and Jimmy compete in a football trivia game where each wrong answer gets a Gatorade cooler full of a mystery substance dumped their heads. Su
Jimmy reads his favorite tweets with the hashtag #TextFail. Subscribe NOW to The Tonight Show Starring Jimmy Fallon: http://bit.ly/1nwT1aN Watch The Tonight S
Chris Evans and his brother Scott take turns putting on noise-cancelling headphones while Jimmy asks them questions about each other and challenges them to matc
Robert Irwin, 13-year-old son of Crocodile Hunter Steve Irwin, shows Jimmy some animals including a Binturong named Orville that smells like popcorn, legless li
Jimmy and Blake Shelton face off against Rose Byrne and Kit Harington in a game of charades. Subscribe NOW to The Tonight Show Starring Jimmy Fallon: http://bi
Jimmy sits down with Good Mythical Morning's Rhett & Link for one of their popular "Will It?" segments, this time testing if soup, edible underwear, dog food an
Matthew McConaughey, Jimmy and The Roots' Tarik Trotter play a game where they take turns confessing a random fact before interrogating each other to determine
James Franco and Jimmy compete in a football trivia game where each wrong answer gets a Gatorade cooler full of a mystery substance dumped their heads. Subscri
Ellen's friend was in the house for a special hour with our host. First, he had to catch her up on the family.